Psoriasis is a chronic, inflammatory, immune-mediated skin disease affecting 1-3% of the adult population. It mainly involves the skin, nails, and joints. However, psoriasis can be associated with several comorbidities, including ocular complications. The most frequently reported pathologies are dry eyes syndrome, blepharitis, and uveitis. Being a systemic inflammatory disease, psoriasis also has the potential to directly affect the retina. It has been reported that ocular manifestations tend to appear much later than skin and joint involvement. Eye complications begin insidiously, and progress asymptomatically. This can lead to a decrease in the quality of life and even permanently compromised visual function if not treated properly. Thus, the present review aimed to present current pathological explanations between psoriasis and ocular manifestation, and to evaluate the prevalence of ocular changes in patients with psoriasis, in order to be diagnosed and managed appropriately.
Ultrasonography (US) is one of the most widely utilized imaging methods in contemporary medical practice. Unlike other imaging techniques primarily within the radiology domain, ultrasonography has been adopted by various medical and surgical specialties and tailored to the specific needs of each. This adaptability has contributed to ultrasonography's rapid diversification and remarkable evolution over recent decades. Ultrasonography was first employed in dermatology in 1979 when Alexander et al. used it to measure skin thickness. However, due to the limitations of conventional ultrasound devices at the time, which had resolutions and frequencies below 15 MHz, detailed elements of the skin could not be analyzed, tempering enthusiasm for the technique [2]. Modern dermatologic ultrasonography began with the development of fixed-frequency devices operating above 20 MHz, enabling detailed visualization of skin structures. Numerous studies on skin physiology and pathophysiology were conducted using this approach. Modern ultrasonography enables us to visualize skin structures, at times surpassing the detail provided by traditional anatomical dissections in educational settings. Given that patient safety and quality medical care remain fundamental priorities, ultrasonography, with its safety profile and versatility, represents the next step in modern dermatology. Ultrasonography represents a rapidly evolving diagnostic tool that holds the promise of significantly improving diagnostic accuracy and the quality of medical dermatology practice.
Background/Objectives: Sepsis and septic shock are critical conditions associated with high mortality rates and substantial impacts on healthcare systems. Accurate and rapid diagnosis is essential for the management of these conditions. The objective of this study is to assess the accuracy of contemporary and traditional methods for diagnosing sepsis and to determine whether improvements have been made concerning the integration of novel diagnostic approaches, to facilitate a prompt diagnosis, taking into account the rapid progression of complications associated with this disease. For this purpose, studies published between 2014 and 2024 were examined to highlight the benefits and limitations of each approach. Methods: A systematic literature review was conducted, including randomized clinical trials, observational studies, and retrospective studies assessing both conventional diagnostic methods (blood cultures and clinical scoring systems) and modern methods (rapid molecular tests, specific biomarkers, and machine learning algorithms). The studies included were selected based on strict design and methodology criteria to ensure a rigorous comparative evaluation of the interventions and technologies used in diagnosing and monitoring patients with sepsis. Results: A total of 23,822 patients were reviewed across the studies included in this systematic analysis. Modern methods, such as continuous monitoring through integrated biosensors and the use of molecular panels for pathogen detection, demonstrated high potential for the early and accurate diagnosis of sepsis. The reviewed studies suggest that these methods can significantly reduce diagnostic time and improve the ability to stratify mortality risk compared to conventional methods. Conclusions: Integrating modern diagnostic technologies, such as rapid pathogen identification tests and specific biomarkers, may complement traditional methods and bring significant benefits in the management of sepsis.
With the increase of the medium lifespan in developing countries, skin aging rise attention more and more. In 2007, Kaya and Saurat rebranded the extreme expression of skin fragility under the name of ‘‘dermatoporosis’’ or chronic cutaneous insufficiency/fragility syndrome. Dermatoporosis is still underused in medical literature and nurses and wound specialists know also about this condition, but they call it “skin tears”. There is obvious confusion cause the nursing literature talks about skin tears while dermatologists write about dermatoporosis. Clinical aspects comprise atrophy, purpura, and pseudo-stellate scars. Firstly, the British dermatologist Thomas Bateman described senile purpura in 1818 as purpuric patches arising in elderly people after minimal trauma, especially on the dorsum of the hands. Furthermore, between 1970 and the full documentation of Kaya and Saurat in 2007, we found medical papers about senile purpura, pseudoscars, skin tears, and so on. Starting from this historical data, they bring valuable information according to clinical aspects, histopathology, ultrasonographic aspects, pathophysiology, and therapeutics. This paper aims to analyze published data for improving the diagnosis and management of dermatoporosis.
Background: Labia minora hypertrophy can lead to aesthetic dissatisfaction and functional discomfort among women, affecting their quality of life and sexual self-esteem. Traditional surgical labiaplasty techniques are effective but are associated with higher complication rates and longer recovery times. This study aims to evaluate the efficacy, safety, and patient satisfaction of laser labiaplasty as a minimally invasive alternative for labia minora reduction. Methods: A retrospective analysis was conducted on 60 female patients who underwent laser labiaplasty. Preoperative assessments included medical history, gynecological examination, and patient-reported concerns. The procedure utilized a CO₂ laser for tissue excision without the need for sutures. Postoperative outcomes were evaluated through follow-up visits and telephone interviews, focusing on complications, recovery time, and patient satisfaction measured by the Subjective Global Aesthetic Improvement Scale (sGAIS). Results: The primary motivations for surgery were aesthetic concerns (85%) and functional discomfort (55%). The mean age was 34.7 years. Minor complications included transient postoperative bleeding (10%) and mild discomfort (25%), with no major complications reported. High satisfaction rates were observed, with 92% of patients reporting significant improvement (sGAIS scores of 4 or 5). Conclusions: Laser labiaplasty is an effective, minimally invasive procedure with high patient satisfaction and low complication rates. It offers a viable alternative to traditional surgical methods for women seeking labia minora reduction due to aesthetic or functional concerns.
Ethnomedicine and ethnobotany have been at the forefront of current scientific focus. The focus of this review is Piper nigrum, for which there exists a wide host of traditional ethnomedical and ethnobotanical applications, recorded mostly from India and the surrounding regions where black pepper is native. These applications cover a wide range of pathologies, including cardiovascular, pulmonary, gastrointestinal, gynaecological, endocrine, integumentary and neurological, and viral diseases and colds. While some of these applications are confirmed by modern research, the majority have not been tested using modern scientific methods, and perhaps many more applications remain to be documented. Finally, it must be noted that some interesting non- medical applications comprise the application of black pepper, as an insecticide/larvicide, are worth further consideration, especially given the newer policies at a European and international level.
Psoriasis is a chronic and complex disease that consists of characteristic cutaneous lesions and is frequently accompanied by systemic comorbidities caused by the chronic inflammatory state. The most common such comorbidities are hypertension, diabetes mellitus, dyslipidemia, inflammatory bowel diseases, depression, anxiety, neoplasia, and non-alcoholic fatty liver disease. Therefore, it is of utmost importance to simultaneously treat both psoriasis and the associated conditions with the best therapies available to improve patients’ life quality. Therefore, this review aims to evaluate the effects of biological therapies on both psoriasis and its comorbidities and also to highlight other future options.
