Background and aim: Acne fulminans is a rare and severe form of acne which usually appears in young men with a personal history of mild to moderate acne. It is characterized by a sudden onset with nodules and ulcerative lesions mostly located on the thorax and extracutaneous manifestations (fever, weight loss, osteoarticular damage). The pathophysiologic mechanism is represented by a type III or IV hypersensitivity reaction to Propionibacterium acnes. Patient: We present the case of a 16-year old patient with acne fulminans. The lesions were accompanied by an impaired general condition with fever and weight loss. Paraclinically an inflammatory syndrome was revealed without osteoarticular changes. It was treated with prednisone 40 mg/day, erythromycin 2g/day and local antiseptic solutions. A gradual tapering of the prednisone dose (5 mg/week) and a dermatological revaluation after 3 weeks to introduce systemic treatment with retinoids were recommended at discharge. Conclusions: Acne fulminans is a severe form of acne with systemic manifestations and corticotherapy is the first line treatment.
Introduction: Solar exposure is a major causative factor for multiple skin pathologies. Even though UV radiation is the most important factor implicated in skin cancer pathogenesis, still, few European countries recognize UV occupational-induced skin cancer as an occupational disease, Romania not being part of this category. The objectives of this study were to evaluate the UV exposure doses in agriculture and construction workers and to establish efficient protective measures. Materials and methods: In our Department, a prospective, observational, analytical study was conducted, including six outdoor workers (in construction and agriculture), over a period of three summer months (July, August, September). Subjects were asked to wear personal dosimeters and the following parameters were analyzed: profession, duration of exposure, UV exposure doses, skin aspect, preexisting preventive measures. Results: The wearing of dosimeters was well tolerated by all subjects, without any interference with daily professional activities. Daily UV radiation doses ranged from 1.79 SED (tractor driver) to 19 SED (agriculture worker). Maximum UVR doses were recorded between 10:00 am and 4 pm. Clinical examination was made after measurements, with no detectable skin changes. Conclusion: Even though workers in agriculture and construction in Romania are exposed to significant UV doses, with 40% more than the general population, these professions are not recognized as high-risk professions for developing skin tumors. More prospective and retrospective studies are necessary for more significant statistical results and for demonstrating the necessity of introducing primary, secondary and tertiary preventive measures.
Unlike the therapy of primary BMS, the treatment of secondary BMS benefits, in addition to symptomatic therapy, from the possibility of using means and methods to correct biological disturbances and/or morphological, psycho-emotional changes respectively. The use of these therapeutic means in secondary BMS is recommended to be established as a first step of therapeutic conduct. Their success is reflected in homeostasis restoring, correcting morphological and functional changes of the field, which frequently leads to no longer use prescription of symptomatic treatment. DEFINITION The International Association for the Study of Pain (IASP) defines burning mouth syndrome (BMS) as a “distinct nosological entity” characterized by “oral sensation of burning or pain, persistent and non- remitting in time in the absence of clinical objective changes of the mouth mucosa” [1]. A relatively similar vision is supported by Grushka (2014). BMS defining a sensory sensation, the author admits that this is manifested mainly by: a) subjective characteristics: taste perception; bilateral burning changes sensation associated with altered taste mouth; sensation of “dry mouth”, although salivary flow is not reduced; perceived foreign body in the oropharynx and b) objective criterion: the oral tissues with clinically normal aspect. The author specifically mentions that the 4 subjective lists, encountered in BMS come forth from the absence of results after an in Corresponding author Bogdan I. Coculescu bogdancoculescu@yahoo.fr objective clinical exam, a defining element for this condition [2]. EPIDEMIOLOGY Setting the epidemiology of BMS is difficult and imprecise because there is no universally accepted definition. The various epidemiological studies often refer to different clinical entities in which oral mucosal lesions lack [3]. This disease has a high rate that varies according to the studies from 0.7% to 14.8 - 15% [3,4,5]. The prevalence of painful syndrome in the Service of Oral Pathology of the Faculty of Dental Medicine - “Carol Davila” University of Medicine and Pharmacy, Bucharest (Romania) is 16.23% [6]. 1 Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest 2 Titu Maiorescu University, Faculty of Medicine, Bucharest, Romania 3 Center for Military Medical Scientific Research, Ministry of National Defence, Bucharest, Romania 43
Background and Aim: Psoriasis is an inflammatory skin disorder with important influence on the lipid profile, insulin resistance and cardiovascular disease. The aim of this study is to compare the lipid profile of classical therapy versus anti-TNFs patients and asses the associated diseases. Methods: We conducted a prospective study. Patients’ data were collected from two Romanian Dermatology Clinics, during the period January 2015 – June 2016. The patients were divided into two groups: study group (on TNF inhibitors) and control group (on classical treatment). Results: The subjects in the study group had more associated diseases and much more patients suffered from dyslipidemia. There were not statistically significant differences in the lipid profile between the two groups. But eliminating patients treated with Acitretin and Methotrexate, a p- value of 0.0259 (significant statistically) was observed when comparing the values of triglycerides in the two groups. Conclusions: We did not observe a beneficial effect of the TNF inhibitors therapy in psoriatic patients on the lipid profile. Subjects on biological treatment suffer from a more severe form of psoriasis vulgaris and associate much more comorbidities.
The aim of this paper was to analyze the data obtained from case reports of oral angiolipoma in terms of age and gender distribution, site of occurrence, nature (intraosseous/ extraosseus) and infiltration. an internet search using Google scholar and Pubmed engine was carried out using search terms ‘angiolipoma’ and ‘oral’/‘mouth’. English literature full text articles and abstracts of oral angiolipoma obtained from 1976-2016 were analyzed for clinical data and presented in this article.
Escherichia coli is the species of the genus Escherichia with the greatest epidemiological impact. Escherichia coli infections are found mainly in places with poor hygiene; the infants with ages between 1 and 3 years old are included in the category with the highest risk. It is a "fecal-oral" transmission mechanism as a result of consumption of contaminated food or water, or by "dirty hands". The foods most commonly implicated in the transmission of the infection are unpasteurized milk and milk products, beef, especially the one insufficiently cooked, unpasteurized fruit juice, lettuce and insufficiently washed vegetables. The disease has been reported worldwide, being described numerous episodes of infection with Escherichia coli that caused multiple illnesses and deaths. Escherichia coli has three types of antigens: antigen "O" (somatic), antigen "H" (flagella) and antigen "K" (capsular). Clinical manifestations are present in the form of non-specific diarrhea, a dysentery form of enteritis, choleriform enteritis, hemorrhagic colitis and hemolytic uremic syndrome (HUS). The Escherichia coli infection diagnosis is made by identifying the etiologic agent and/or by highlighting the VTI toxin in the feces. The treatment consists in precautionary antibiotherapy, hydrodynamics and electrolyte rebalancing, blood transfusions and dialysis, if in the case of renal failure. The prevention of infections with Escherichia coli is achieved by personal hygiene, food hygiene and work hygiene.
The continuously increasing number of medical investigations using radiological methods imposes the strong necessity of informing patients about benefits and risks regarding radiation absorbed doses. Tracking the radiation doses absorbed by patients must be a future challenge of any medical system. The effective doses received by patients in many types of medical investigations must be calculated, transformed, recorded and cumulated. Doctors and patients must be very responsible in prescribing or demanding new radiological medical investigations. Radiological international legislation, guidelines, programmers and practice supervised by standards, commissions on radiology protection must include new specific measures for patients’ cumulated doses. A pilot Romanian project had tried to accomplish some of these tasks. INTRODUCTION Radiation is commonly associated with nuclear accidents or modern irradiative artificial sources such as: mobile phones, great antennas, satellites, food irradiation, and radioactive building materials. Generally, radiation is associated with all kind of human activities. As a huge surprise, in fact, radiation is quite a natural phenomenon in our lives. There are many radioactive substances in air, water and soil that are called natural background radiation. During a long airplane flight one can also receive an important radiation dose. Typically doses from natural sources are measured in mSv. The Sievert (Sv) is the International System of Units (SI) derived unit for radiation dose. There are many other different units for absorbed radiation and transformations can be made in order to compare them. A recent United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) publication [1] estimates worldwide distribution of radiation exposure: • 13% from cosmic sources • 16% from soil • 9% from food • 20% from medical investigations • 42% from radon sources Radon-222 is a radionuclide in the form of a gas that normally emanates from the soil. Radon is a colorless, 1 Polytechnic University, Bucharest 2 Carol Davila Central University Emergency Military Hospital, Bucharest 3 S.C. CERTSIGN S.A. Bucharest 5
