Due to its scarcity, the basosquamous carcinoma represents a challenging pathology both as a result of its aggressiveness and potential of relapse and metastases, and also due to unclear management guides. Encountered under the name of basal cell carcinoma or metatypical carcinoma, the pathophysiology of such tumors is still unclear and it is not known yet if it either derives from a basal cell carcinoma or it could be a variant of transition to a squamous cell carcinoma. Due to low incidence, unclear treatment protocols and not enough research regarding squamous component in the aggressivity of basosquamous carcinoma, the aim of this paper is to analyze histopathological features of 5 cases of basosquamous carcinoma from Plastic Surgery Department of Emergency University Hospital, Bucharest, and correlate them with current literature.
Breast carcinoma represents the leading cause of oncologic mortality for women. Due to therapeutic and diagnostic advances, the mortality and morbidity in the last decade declined, but breast cancer still has a great impact on quality of life and also on medical service cost. In the light of these facts, an integrated approach, considering histopathology features, molecular profiles and corroboration with clinical and imagistic data is necessary. A descriptive retrospective one-year study analyzed the breast cancer heterogeneity in 121 cases registered in the Pathology Department of the University Emergency Hospital in Bucharest, Romania. Our purpose was to evaluate histopathological, immunohistochemically, clinical and imagistic aspects of breast cancer considering the current molecular classification (Luminal A, Luminal B, HER2 enriched and triple negative/basal like). Our assay revealed that most prevalent histotype was NST (no special type) followed by invasive lobular carcinoma. Considering the molecular pattern, the most common was luminal B. Triple negative basal like and HER 2-enriched were correlated with an aggressive morphologic pattern and lymph-nodes positivity. Considering the imagistic acquisitions, mammography proved to be the most accurate technique for measuring the dimension of NST. In conclusion, breast carcinoma is a heterogeneous disease that needs an integrated approach and personalized treatment based on the histopathologic and molecular features. Considering the great number of advanced stages as diagnosis, a national screening program for breast cancer is imperiously needed.
