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Basosquamous carcinoma: an overview of actual protocol and the importance of basal and squamoid components

Anamaria Grigore1, 2, Ana Maria Oproiu1, 2,*, Mariana Costache2, 3, Oana M. Patrascu2, 3, Adrian Dumitru2, 3, Mihaela I. Zaharia1, Alexandru Adrian1, 2, Constantin Condrea1, Ioan P. Florescu2

1 - Department of Plastic Surgery, Emergency University Hospital, Bucharest, Romania

2 - Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

3 - Department of Pathology, Emergency University Hospital, Bucharest, Romania

Correspondence: Ana-Maria Oproiu

DOI: https://doi.org/10.55453/rjmm.2022.125.3.6

Received: January 10, 2022

Accepted: April 28, 2022

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Abstract:

Due to its scarcity, the basosquamous carcinoma represents a challenging pathology both as a result of its aggressiveness and potential of relapse and metastases, and also due to unclear management guides. Encountered under the name of basal cell carcinoma or metatypical carcinoma, the pathophysiology of such tumors is still unclear and it is not known yet if it either derives from a basal cell carcinoma or it could be a variant of transition to a squamous cell carcinoma. Due to low incidence, unclear treatment protocols and not enough research regarding squamous component in the aggressivity of basosquamous carcinoma, the aim of this paper is to analyze histopathological features of 5 cases of basosquamous carcinoma from Plastic Surgery Department of Emergency University Hospital, Bucharest, and correlate them with current literature.

Keywords:
basal cell carcinoma, basosquamous, metatypical carcinoma, squamous cell carcinoma

Basosquamous carcinoma: an overview of actual protocol and the importance of basal and squamoid components

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APA Style

Grigore, A., Oproiu, A.M., Costache, M., Patrascu, O.M., Dumitru, A., Zaharia, M.I., Adrian, A., Condrea, C., & Florescu, I.P. (2025). Basosquamous carcinoma: an overview of actual protocol and the importance of basal and squamoid components. Romanian Journal of Military Medicine, 125(3), 391-400. https://doi.org/10.55453/rjmm.2022.125.3.6

Vancouver Style

Grigore A, Oproiu AM, Costache M, Patrascu OM, Dumitru A, Zaharia MI, et al. Basosquamous carcinoma: an overview of actual protocol and the importance of basal and squamoid components. Rom J Mil Med. 2025;125(3):391-400. doi:10.55453/rjmm.2022.125.3.6.

Harvard Style

Grigore, A., Oproiu, A.M., Costache, M., Patrascu, O.M., Dumitru, A., Zaharia, M.I., Adrian, A., Condrea, C. & Florescu, I.P. 2025, 'Basosquamous carcinoma: an overview of actual protocol and the importance of basal and squamoid components', Romanian Journal of Military Medicine, vol. 125, no. 3, pp. 391-400, doi:10.55453/rjmm.2022.125.3.6.