Orthodontic treatment and periodontal disease can have an inter-conditional relationship, particularly when the accumulation of bacterial plaque, favoured by orthodontic appliances and poor oral hygiene can cause periodontal inflammation. The objective of the study is to highlight the influence of the risk factors’ polymorphism on the therapeutic response in periodontal disease. 64 patients with mixed or definitive dentition and poor oral hygiene were included in the study, of whom 22 patients followed treatment with fixed orthodontic dispensers, 22 patients were treated with mobile orthodontic braces and 20 were non-attendants. From all patients gingival crevicular fluid was collected and assessed, before and after applying a chlorhexidine-based gel antiseptic agent.
