Introduction: Sepsis is a life-threatening organ dysfunction due to a dysregulated host response to an infection1 and also an important worldwide health problem. Recent progresses in understanding pathogenesis are reflected in increasing emphasis put on time (Sepsis Update 2018 decreased the time for diagnosis and treatment from 3- 6 hs Sepsis- 2 to 1 hour). The aim of the study was to combine an early warning score (increased sensitivity- NEWS2) and a biomarker (increased specificity- presepsin) in order to detect earlier an acute illness (infection) before becoming life-threatening. Materials and methods: It was a retrospective, single-center observational cohort study of 125 consecutive patients who were diagnosed with systemic inflammatory response syndrome between July 2016 and July 2018 at Emergency Department of “Dr. Carol Davila” Central Military Emergency University Hospital, Bucharest, Romania in order to determine sooner, which patient will further develop a sepsis. We used the area under receiver–operator characteristic curves (AUC) to assess the overall discriminatory power of NEWS2, MEDS and presepsin in detecting sepsis, septic shock and the probability of death on admission and compared them with combined scores between NEWS2 and presepsin. Results: Using a combined score and a simple algorithm, the NEWS2 score had changed (12,8%) for 16 patients. For 10 out of 95 (10,52%) without sepsis and 6 out of 30 (20%) of septic patients, more points were added to NEWS2 meaning that more septic patients were diagnosed before an infection become life-threatening Conclusions: In the present study, we have tried to assess the impact of a monitoring score and a rapid POCT biomarker, in a condition when time is of critical importance. Using a verified early warning score, NEWS2, with increased sensibility and low specificity and presepsin, POCT biomarker with increased specificity, we diagnosed sepsis earlier in a number of cases.