Gestational diabetes (GDM) is characterized by the initial onset of elevated glucose levels while pregnant throughout the 24th week up until the 28th week of gestation affecting around 2
Background: Infection and sepsis represent major complications after abdominal surgery for secondary peritonitis. Finding new tools that can help identify patients at risk for developing postoperative complications is of the utmost importance for clinicians. We tried to evaluate the use of different biomarkers in evaluating the postoperative prognosis of patients with secondary peritonitis. Methods: We searched the available literature on the usefulness of serum biomarkers in evaluating prognosis in patients with secondary peritonitis. Results: Elevated postoperative lactate levels and high procalcitonin (PCT) levels were associated with negative outcomes. C-reactive protein values increase rapidly in response to the surgical insult but have no value in assessing the overall prognosis. Conclusion: Procalcitonin (PCT) is superior to other biomarkers in predicting severe septic complications and overall mortality in patients with secondary peritonitis.
Background: Although locoregional anesthesia techniques in total knee arthroplasty (TKA) have progressed steadily, the emergence of the adductor canal block representing a step forward for postoperative evolution in preservation of the quadriceps muscle strength, analgesia of the posterior territory of the knee still remains a challenge. The emergence of IPACK, in association with earlier techniques, offers promising preliminary results in terms of its contribution to a favourable evolution and to the satisfaction of TKA patients. Materials and methods: Prospective trial performed on a group of 28 patients undergoing a total knee arthroplasty intervention; analgesia control in the postoperative period was performed either with opioid and nonopioid systemic analgesics, or by associating the continuous adductor canal block with IPACK and systemic analgesics. The primary objective is pain control at rest/on mobilization, while the secondary purpose is analysis of opioid use, their side effects and recovery of joint mobility. Results: There is a significantly better pain control in the group of patients with locoregional anesthesia, both at rest and on mobilization (p<0.005), accompanied by a decrease in opioid use (p<0.00001) and the related adverse reactions; at the same time, there is an improvement in the functional recovery of the knee joint, quantified by the flexion degree at 24 and 48 hours after surgery ( 61.5/71.12 degrees for continuous adductor canal block with IPACK versus 45.14/55.42 degrees for general anaesthesia) Conclusions: The introduction of peripheral nerve blocks in the multimodal analgesia regimen after TKA results in better control of postoperative pain, both at rest and on mobilization, in a decrease in opioid use and their related adverse reactions and in an improved recovery of joint range of motion, as well.
