Background/Objective: In order to address the current knowledge gap with regard to serum calcium-to-magnesium ratio (Ca/Mg) in patients with adrenal incidentalomas, we aimed to analyze Ca/Mg in menopausal women diagnosed with these tumors versus (tumor-free) controls across DXA categories. Methods. This is a retrospective, real-world, cross-sectional study in 474 menopausal women admitted at a single tertiary center of endocrinology. Results. Tumor group (N=111) had osteoporosis/osteopenia/normal DXA prevalence: 17.1%, 36.9% and 46%, respectively, control group: 13.8%, 45.5%, and 40.8%. Ca/Mg ratio was similar between DXA sub-groups in each group. Tumor group: Ca/Mg corelated with age (r=0.288, p=0.047), P1NP (r= -0.459, p=0.011), osteocalcin (r= -0.37, p=0.026) and CrossLaps (r= -0.446, p=0.006) in subjects with normal DXA (N=51), while in those osteoporotic (N=19), with glycated hemoglobin A1c (r=0.596, p=0.025). Control group (N=363): Ca/Mg corelated with age (N=165, r=0.178, p=0.034), fasting glycemia (r=0.253, p=0.003), glycated hemoglobin A1c (r=0.22, p=0.045), osteocalcin (r= -0.196, p=0.03), and CrossLaps (r= -0.193, p=0.034) in osteopenic subjects (N=165) and with P1NP (r= -0.249, p=0.027) in normal DXA (N=148). Conclusion. Osteopenic subjects (regardless tumor diagnosis) showed a direct age-Ca/Mg association, while the ratio was correlated with the bone turnover biomarkers distinctively across DXA sub-groups. Additionally, the ratio might reflect a more severe glucose profile.
Magnesium alloys represent a new research direction in the field of orthopedic resorbable metal materials, because it has several important properties that recommend it as an excellent resorbable biomaterial for implants. From in vitro studies, Magnesium has osteoconductive properties, promoting the formation of new bone by stimulating the adhesion of osteoblastic cells, this leading to the idea that it will induce formation of hard callous at fracture site. The present study followed the in vivo evaluation of the biodegradation of pins made of Mg-1Ca alloy introduced centromedulary in rabbit tibiae, with previously induced experimental fractures. The influence of the biodegradation process on the formation of the bone callus was evaluated through radiological images and histopathological examinations. At the same time, we evaluated the function of vital organs through histopathological examinations and blood tests. We chose intramedulary nailing (IMN) with pins, because in orthopaedic surgery this is the golden standard for fractures of tibia or femur. In the radiological images obtained, we notice callus formation at the level of the experimental fracture at 6 weeks after surgery. The histological sections made from the samples collected from the fracture zone adjacent to the Mg1Ca alloy implant, confirm the formation of the bony callus. The trichrome Masson sections show a normal bone development with newly formed bone tissue at the tissue - alloy interface. In the sections harvested from the vital organs, no pathological changes are observed. These observations suggest that the biodegradation process of the Mg-1Ca alloy do not interfere negatively with the biological process of bone formation, allowing the formation of the bone callus and do not confirm the suspicion of pathological changes induced by systemically released corrosion products and gas embolism in vital organs.
There are conflicting data on the effects of magnesium on hypertension in the literature. Therefore we aim this study to investigate whether there is a relationship between serum magnesium levels and hypertension in newly diagnosed. This is a case-control study. The patients were selected from the records of patients who applied to the family medicine outpatient clinic between June 2016 and May 2017. A total of 276 patients, 68 patients with newly diagnosed hypertension in the case group and 208 patients without any disease in the control group were included in the study. Binary logistic regression analysis was performed between the case and control groups. The odds ratio for magnesium was 0.1 (0.012-0.810). When the value of the magnesium variable increases by 1mg/dl, the risk of hypertension decreases by 90%. However, in the presence of magnesium as an independent variable, the predictability rate of our model was expected to increase but decreased. The odds ratio for age was
