Objective: Currently, the global epidemiologic impact of obesity requires continuous seeking of practical biomarkers; hence, this current study aimed to address the gap of chemerin assays in obese versus non-obese females and to analyze its circulating levels in relationship with the glucose profile and other circulating adipokines. Methods: This is an exploratory, prospective, cross-sectional analysis in females aged between 50 and 80 years. We excluded individuals with diabetes, cancers, endocrine, kidney, cardiovascular, and bone conditions. Enzyme-linked immunosorbent assay-based circulating adipokines testing was performed. The final analysis was focused on circulating chemerin (ng/mL) in the obese [body mass index (BMI) ≥ 30 kg/sqm] versus non-obese (BMI < 30 kg/sqm) group. Results: The obesity (N=12) versus the non-obesity (N=12) group showed a statistically significantly higher HOMA-IR (p=0.04), fasting insulin (p=0.01), but similar circulating chemerin. Chemerin positively correlated with BMI only in the obesity group (r=0.881, p=0.0039), but not with patients’ age and glucose profile-based features in any group. Chemerin showed a statistically significant positive, strong correlation with VEGF-A level (r=0.857, p=0.0065) and an inverse statistically significant strong association with circulating leptin (r= -0.713, p=0.0092) and circulating IL-12 p40 (r= -0.829, p=0.0416) in the obesity group. Conclusion: As a potential hypothesis-generating analysis, this pilot study showed different statistical results in BMI-based groups, despite the fact that direct comparison of circulating chemerin and even leptin, VEGF-A, and IL-12 p40 did not reach between-group statistical significance. A larger sample size and a multimodal integration of the adipokines panel might serve for practical points in addressing obesity. Citation: Schipor SV, Manda D, Ciobica ML, Sima OC, Preda EM, Ciuche A, et al. Exploratory results of circulating chemerin testing in humans. R. J. Mil. Med. 2026, CXXIX(4): 404-412 https://doi.org/10.55453/rjmm.2026.129.4.6 Academic Editor: Raluca Mititelu
The study aimed to investigate serum vaspin and chemerin changes in response to combat physical fitness tests in military forces. In a semi-experimental design with pretest and posttest, twenty volunteers were engaged to participate in the study. Combat Physical Fitness Test consisted: (1) 25-yard(yd) sprint to J-hook, to 25-yd crawl, and 25-yd run through cones to 75-yd line; split (2) 75-yd casualty drag; split (3) ammo can run to grenade toss (75-yd); (4) ammo can run to end (75-yd); and (5) 650-yard endurance run. Pre-test and the post-test blood sample was gained. The data were analyzed by SPSS version 24. Serum chemerin did not change significantly compared to the pre-test whereas Serum vaspin was significantly higher after the test (p = 0.018). Afterward, a direct correlation was observed between serum chemerin and serum vaspin (p = 0.034, r=0.335). It is suggested that serum vaspin is responsive to short-term maximal power output activity required in the combat fitness test and positively correlates with chemerin. However, it appears that 3 to 4 minutes of high-intensity exercise induce comparatively moderate post-exercise serum vaspin increment, which appears to be inadequate to stimulate chemerin secretion.
