Abstract Cervical cancer remains a major global public health challenge, especially affecting women of reproductive age. In the context of a societal shift towards delayed childbearing, fertility preservation has become an integral component of oncologic care for early-stage disease. Radical trachelectomy has emerged as a viable fertility-sparing surgical option in carefully selected patients. This review aims to assess the role of fertility-sparing radical trachelectomy in the modern management of early-stage cervical cancer by emphasizing the evolving criteria for patient selection, advances in surgical techniques, and the critical balance between oncologic safety and reproductive potential. An analysis of the literature from the past two decades shows that radical trachelectomy, whether performed via vaginal or abdominal routes, provides excellent oncologic control for early-stage lesions. Therefore, optimal results of such a technique depend on careful patient selection along with a multidisciplinary approach in order to reduce obstetrical complications.
Background and Aim: This study aimed to investigate the expression level of Sine oculis homeobox homolog 1(SIX1) in normal and cancerous cervical tissues. Methods: Real-time PCR was used to evaluate SIX1 expression level in fresh surgically obtained cervical biopsies. Also, cervical specimens were tested for HPV DNA detection by MY09/11, GP5+/6+ nested PCR method. Results: The expression level of SIX1 mRNA in Cervical cancer was markedly higher than in normal cervical tissue (p<0.0001). Moreover, HPV DNA was detected in 100% of cases and 21.05% of controls (P<0.0001). Conclusions: This finding indicates that increased SIX1 expression might be of relevance to the pathogenesis of cervical cancer. Perhaps, studies to find agents that specifically target SIX1, develop novel anti-cancer and anti-metastasis drugs. This idea has to be investigated in future clinical studies.
