1 - Department of Plastic Surgery and Reconstructive Microsurgery, ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2 - Burn Centre, Emergency Clinical Hospital of Bucharest, Bucharest, Romania
3 - Plastic and Reconstructive Surgery Department, "Dr Carol Davila" University Central Emergency Military Hospital, Bucharest, Romania Correspondence: Andreea Grosu-Bularda, andreea.grosu-bularda@umfcd.ro
DOI: https://doi.org/10.55453/rjmm.2024.127.6.8
Received: July 13, 2024
Accepted: October 2, 2024
Burn injuries are among the most severe forms of trauma, often leading to multiple organ dysfunction syndrome (MODS), a major contributor to morbidity and mortality in burn patients. This review examines the pathophysiological mechanisms, clinical manifestations, and management strategies associated with MODS in burn patients. Following a severe burn injury, the systemic inflammatory response and subsequent release of pro-inflammatory cytokines precipitate dysfunction across various organ systems. Early recognition and aggressive management of MODS, including fluid resuscitation, infection control, and organ support, are crucial for improving survival outcomes. A comprehensive understanding of the multifactorial etiology and interrelated nature of organ dysfunction in burn patients is essential for developing targeted therapies and optimizing patient care. This review provides a current overview of the topic. In the coming years, new insights into the pathophysiological mechanisms are expected to enhance our comprehension of the subject further.
Bordeanu-Diaconescu, E.M., Frunza, A., Grama, S., Andrei, M.C., Dumitru, C.S., Marinescu, B.M., Costache, R.A., Lascar, I., & Grosu-Bularda, A. (2025). Comprehensive review and update on multiple organ dysfunction syndrome in burn patients: pathophysiology, risk factors, and management strategies. Romanian Journal of Military Medicine, 127(6), 480-490. https://doi.org/10.55453/rjmm.2024.127.6.8
Bordeanu-Diaconescu EM, Frunza A, Grama S, Andrei MC, Dumitru CS, Marinescu BM, et al. Comprehensive Review and Update on Multiple Organ Dysfunction Syndrome in Burn Patients: Pathophysiology, Risk Factors, and Management Strategies. Rom J Mil Med. 2025;127(6):480-490. doi:10.55453/rjmm.2024.127.6.8.
Bordeanu-Diaconescu, E.M., Frunza, A., Grama, S., Andrei, M.C., Dumitru, C.S., Marinescu, B.M., Costache, R.A., Lascar, I. & Grosu-Bularda, A. 2025, 'Comprehensive Review and Update on Multiple Organ Dysfunction Syndrome in Burn Patients: Pathophysiology, Risk Factors, and Management Strategies', Romanian Journal of Military Medicine, vol. 127, no. 6, pp. 480-490, doi:10.55453/rjmm.2024.127.6.8.
