Evaluation of the effect of drug on physiotherapy methods on cytokines and chemokines of Covid-19 patients

Alieh Rezazadeh¹, Mohammadreza H. Rasanani^{1,* ✉}, Jalal Nourmohammadi², Mohsen Akhondi³, Zahra S.H. Vaeaz⁴, Mahdieh H. Moghadam⁵

1 - School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran
2 - Pediatrics Department, Shahid Hasheminejad Medical Research Center, Mashhad University of Medical Sciences, Iran
3 - Pediatric Anesthesiologist Fellowship, Herzzentrum Leipzig, Germany
4 - Department of Nursing, Mashhad Branch, Islamic Azad University, Mashhad, Iran
5 - Management Department, Mashhad University of Medical Sciences, Iran diarrhea, skin complications, rapid breathing, palpitations, hypotension, seizures, headache, hallucinations and tremors. Researchers have now discovered in a new study to look at the progression of coronavirus infection in mice that the cytokine storm is a vicious cycle caused by the overproduction of two signaling proteins called "tumor necrosis factor alpha" (TNF) - "interferon gamma". (INF) is caused by th e body's immune system. Together, these two proteins lead to serious conditions that can eventually lead to inflammation, organ damage, and even death. But this study in mice showed that using pre- existing antibodies to fight these proteins is an effective way to prevent death in cases of severe Covid-19 infection. The researchers noted that knowing these pathways and the mechanisms that stimulate this inflammation are very important for devising effective treatment strategies. The researchers also identified specific cytokines that activate

Correspondence: Mohammadreza Hadian Rasanani

DOI: https://doi.org/10.55453/rjmm.2022.125.4.10

Received: February 9, 2022

Accepted: May 18, 2022

Abstract:

Previous investigations have demonstrated that interleukin-6 (IL-6), C reactive protein (CRP), tumor necrosis factor- alpha (TNF-alpha), in Coronavirus disease 2019 (COVID-19) patients are considerably increased, and their progressive elevation are clinical threat indicators of disease severity. The purpose of this systematic review is to evaluate the efficacy of physiotherapy, specifically chest physiotherapy, on different cytokines in Covid-19 and non-covid-19 patients. The main complications and symptoms of this virus are as follows; a dry cough, fever, and progressive dyspnea. Quickly, the coronavirus, which is named SARS-CoV-21, has spread worldwide, causing severe lung inflammation, respiratory distress syndrome, cardiac and renal injury, especially in comorbidities patients. Approximately 96% of the cases experience mild respiratory symptoms; some progress to pneumonia, respiratory insufficiency, acute respiratory distress syndrome, and multiorgan failure. The overall mortality rate per number of diagnosed cases is 4.6%; it can range from 0.2% to 15% according to age and health problems. Combination MeSH and text terms were used to perform the search strategy. Interventions in RCTs and clinical trials with or without comparison were assessed. Six studies met the inclusion criteria. Studies demonstrated that physiotherapy could have an effect on TNF-alpha, IL-6, IL-10, IL-1β and CRP.