Deregulation of the Hippo Signaling Pathway in Virus-Associated Cancer

Emad Behboudi¹, Mohammad S. Hashemzadeh², Ali Ramezani³, Ali Jari⁴, Negar Ebrahimi⁵, Somayeh Ghasemi⁶, Manoocher Makvandi³, Tahereh Gholamzadeh⁷, Ebrahim Faghihloo^{8,* ✉}

1 - Department of Microbiology, Golestan University of Medical Sciences, Gorgan, Iran; behboodi_emad@gmail.com
2 - Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran; msh.biotechnology@gmail.com
3 - Virology Department, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; ramezaniali73@gmail.com (AR);
4 - School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; ali.jari@gmail.com
5 - Department of Nursing, School of Nursing and Emergency Medicine, Poldokhtar Branch, Lorestan University of Medical, Lorestan, Iran; nebra781@gmail.com
6 - Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; somighasemi88@yahoo.com
7 - Department of Obstetrics and Gynecology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; ensieh.gholamzadeh70@gmail.com
8 - Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; faghihloo@gmail.com

Correspondence: Ebrahim Faghihloo, aghihloo@sbmu.ac.ir

DOI: https://doi.org/10.55453/rjmm.2023.126.2.8

Received: September 22, 2022

Accepted: January 7, 2023

Abstract:

Hippo signaling has been recognized as a newly identified tumor suppressor signaling pathway that can regulate cellular processes including regeneration, cell death, differentiation, and development. Its dysregulation through overexpression of YAP (Yes-associated protein) and TAZ (PDZ-binding motif) as two main oncogenic factors of the Hippo pathway has a crucial role in several cancers. Because of the limited prognosis and therapeutic targets, further understanding of molecular pathways involved in tumorigenesis is one of the interesting issues in studies. Here, we demonstrated that some viruses, through dysregulation of the Hippo signaling pathway can be implicated in transformation, metastasis, and chemotherapeutic drug resistance in virus-related cancer and also help processes involved in the pathogenesis of viral infection such as persistence.