Objective: This study aimed to examine the relationship between mental adjustment mechanisms and somatic symptoms in cancer survivors, a topic with limited research in Psycho-oncology. Methods: In this exploratory cross-sectional study, 88 cancer patients were surveyed using the Somatic Symptoms Scale (SSS-8), the Somatic Symptom Disorder Scale (SSD-12), and the MiniMental Adjustment to Cancer Scale (MINI-MAC). Additional questions were asked regarding cancer stage, treatment, and illness relapses. Data collection occurred over one month at a local oncology unit. Results: Several significant correlations were observed between the scales and subscales of the instruments applied during this study. The most important results showed that maladaptive adjustment mechanisms were significantly associated with somatic symptoms, while adaptive mechanisms were not. However, "fighting spirit," an adaptive mechanism, acted as a moderator between somatic symptoms and their psychological impact (effect size t = 0.157, p < 0.05). Lower "fighting spirit" scores correlated with higher SSS-8 and SSD-12 scores, indicating its potential protective role. Conclusion: A more specific assessment of somatic symptoms and their link to mental adaptation to cancer is needed. Psycho-oncological interventions should address both adaptive and maladaptive adjustment mechanisms due to their significant influence on patient outcomes.
Paneth cells (PCs) are specialized epithelial cells located at the base of the crypts of Lieberkühn in the small intestine and colon, that have been occasionally identified in colorectal adenomas and adenocarcinomas. Their presence in these lesions has raised questions regarding their role in colorectal neoplasia and their potential association with adenoma burden. To understand their potential role in carcinogenesis, we conducted an extensive review of the available literature on PubMed, focusing on the occurrence, molecular mechanisms, and implications of Paneth cells in neoplastic lesions of the colorectum. This review synthesizes current findings and discusses the potential of Paneth cells as diagnostic biomarkers and therapeutic targets in colorectal cancer.
ISSN: 1222-5126 (print), 2501-2312 (online)
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