Two major trials, EMPA-REG OUTCOME trial (with Empagliflozin) and CANVAS trial (with Canagliflozin) have demonstrated the beneficial effects of SGLT2 inhibitors in patients with type 2 diabetes at risk for heart failure. SGLT2 inhibitors possess a unique pharmacological profile and have shown a significant reduction of hospitalization for heart failure in diabetic patients, immediately after treatment commencement. It seems that their effects are beneficial both in heart failure with reduced ejection fraction and heart failure with preserved ejection fraction. SGLT2 inhibitors reduce cardiovascular endpoints in patients with diabetes and high cardiovascular risk, most likely through a reduction of heart failure-related events. Empagliflozin treatment exerts beneficial effects on vascular function and central haemodynamics. Various mechanisms seem to contribute to the beneficial effects of SGLT2 inhibitors in heart failure. Taking into consideration their cardiovascular benefits and the number of ongoing trials with these drugs, there is a possibility to expand their indication to nondiabetic patients with heart failure. This review focuses on the newest insights into the beneficial effects of SGLT2 inhibitors on the cardiovascular system.
Background: Self-care behaviors are very important to control type 2 diabetes. The current study was conducted aiming at determining the effect of the educational intervention based on mobile short message service on the self-care behaviors in patients with type 2 diabetes in Khorram Abad. Methods: This study was a semi-experimental study on 191 patients with type 2 diabetes (45 cases and 45 control). Data collection tools included a demographic information form, International Physical Activity Questionnaire, Self-Care Scale, and Self-Efficacy Scale. Three to four educational messages were sent daily through mobile phones as an educational intervention. Data were analyzed with SPSS V24 at a significance level of 0.05. Results: The data analysis indicated that the average score of self-care, self-efficacy, and blood sugar was significantly higher in the case group than in the control group before and after the intervention (P<0.001). However, in terms of the physical activity variable, this relationship was not statistically significant in the case and control groups. Conclusion: Educational interventions to empower diabetic patients by strengthening their self-care can be an effective way to improve the health of diabetic patients. Therefore, it is suggested to use patient empowerment programs, especially with a self-care approach, to improve the health of patients.
