Introduction. Even though, primary thyroid lymphoma (PTL) is a rare thyroid malignancy and extranodal non-Hodgkin lymphoma, this type of disease should not be disgraced in order to achieve an early diagnosis and multimodal treatment. Materials and method. We selected for discussions a primary thyroid lymphoma patient with absent constitutional (B-type) symptoms, who undergoes a multidisciplinary approach of the disease, chemotherapy and radiotherapy. In this clinical case report a 84 yo male patient with stage IE diffuse large B-cell histological type (Ann Arbor staging) was treated using R-CHOP chemotherapy, followed by involved field radiotherapy, with an excellent treatment response and disease control. Results and Discussion. Usually this type of extranodal non-Hodgkin lymphoma is present in the seventh decade of life, with males being affected earlier than females. One of the most common presentations of thyroid lymphoma is an enlarging neck mass and a history of Hashimoto’s thyroiditis, which is the major risk factor. The most common PTL subtypes are diffuse large B-cell lymphoma (the most aggressive histological subtype, representing 70% of all PTLs) and MALT lymphoma (30% of the PTLs). Advances in both diagnosis and treatment in the last years have improved the early diagnosis and shortened the time for treatment implementation.