Introduction: Burn is a tissue injury and affects social functioning and relationships. Complications of burns lead to disruption of social relationships and consequently social dysfunction. Objective: Aim of this study was to determine the effect of multimedia training on social functioning of burn patients in Shahid Motahhari hospital in Tehran. Methods: This clinical trial study was performed on 100 burned patients. The intervention group received a multi-media self-care discharge training on a CD in addition to the common education. Social function of quality of life was examined in both groups before intervention, 3 months and 6 months after intervention. Conclusion: Results showed that before intervention the mean score of social function of quality of life in intervention and control group was 1/55± 0/46, 1/92± 0/6 respectively which was statistically significant (p <0.001). Mean and standard deviation of social function of quality of life in the intervention and control groups three and six months after intervention were 2/47± 0/56, 4/05± 0/77, 2/15±0/39, 3/29 ± 0/95 respectively which was statistically significant (p <0.001).