1 - Neurology Department, Fundeni Clinical Institute, Bucharest, Romania
2 - Gastroenterology and Hepatology Department, Fundeni Clinical Institute, Bucharest, Romania
3 - Neurology Department, Carol Davila University Central Emergency Military Hospital, Bucharest, Romania
4 - Radiology and Medical Imaging Department, Fundeni Clinical Institute, Bucharest, Romania
5 - Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
DOI: https://doi.org/10.55453/rjmm.2023.126.3.12
Received: February 3, 2023
Accepted: March 2, 2023
Background: It is well known that patients with polycystic kidney disease (PKD) are at increased risk of developing cerebral aneurysms, however, this association has not been well studied for patients with polycystic liver disease (PLD). Material and methods: Cross-sectional descriptive study, which included 15 adult patients diagnosed with polycystic liver disease at the Gastroenterology and Hepatology Department of Fundeni Clinical Institute. Standard neurological exam and brain MRI were performed in all patients on a 1.5 Tesla MRI. Brain imaging protocol included T1/T2, T1SE, T2-FLAIR, DWI, SWI, 2D-TOF, 3D-TOF. Results: The majority of patients (93%) were females. The mean age was 53 ± 5 years old. Patients with AD-PKD and polycystic hepatic disease predominated (60%). Aneurysms were found in only one patient diagnosed with AD-PKD (in whom three aneurysms were described). The overall prevalence of cerebral aneurysms in our patient group was 7%. However, none of the patients with isolated PLD was found to have intracranial aneurysms. Other brain imaging abnormalities were frequent but nonspecific (mostly attributable to vascular-degenerative changes). Conclusions: Given these results, and due to the small number of patients in our study, it is hard to appreciate if polycystic liver disease is indeed associated with an increased risk of cerebral aneurysms.
Lupescu, I.C., Iacob, S., Lupascu, N., Lupescu, I.G., Pietrareanu, C., & Gheorghe, L. (2025). The prevalence of cerebral aneurysms in patients with polycystic liver disease. Romanian Journal of Military Medicine, 126(3), 317-321. https://doi.org/10.55453/rjmm.2023.126.3.12
Lupescu IC, Iacob S, Lupascu N, Lupescu IG, Pietrareanu C, Gheorghe L. The Prevalence of Cerebral Aneurysms in Patients with Polycystic Liver Disease. Rom J Mil Med. 2025;126(3):317-321. doi:10.55453/rjmm.2023.126.3.12.
Lupescu, I.C., Iacob, S., Lupascu, N., Lupescu, I.G., Pietrareanu, C. & Gheorghe, L. 2025, 'The Prevalence of Cerebral Aneurysms in Patients with Polycystic Liver Disease', Romanian Journal of Military Medicine, vol. 126, no. 3, pp. 317-321, doi:10.55453/rjmm.2023.126.3.12.
