1 - Emergency University Hospital of Bucharest, Bucharest, Romania
2 - "Carol Davila" University of Medicine and Pharmacy Bucharest, Romania
3 - Central Military Emergency University Hospital “Dr. Carol Davila”
4 - University of Bucharest, Bucharest, Romania
5 - "Grigore T. Popa" University of Medicine and Pharmacy Iasi, Romania
Received: November 12, 2020
Accepted: January 5, 2021
Stroke has a significant prevalence in Romania. The predisposition for this multifactorial disease is partially known. The aim of this study is to investigate the predisposition for stroke in Romanian population. Material and methods. We selected cases with recent ischemic stroke (n=100) and healthy control subjects (n=100). The AGTR1 A1166C (rs5186) polymorphism was genotyped by restriction of amplicons with Dde I endonuclease. Results. Active cigarette smoking (O.R. =6.92, p=0.0001) or presence of the AT1R C variant (O.R. =6.69, p=0.0006) in overweight or obese women significantly increase the risk for ischemic stroke. The diagnosis of stroke (71.5 vs 68 years old) or T2DM (63.39 vs 60.77 years old) was recorded at an older age in women compared to men (p<0.05). Obesity considered independent (O.R. =4.22, p<0.05) or in association with T2DM (O.R. = 10.16, p=0.0002) confers the highest risk of stroke when compared to women. Conclusions. Obesity in association with T2DM confers the highest risk of stroke for men when compared to women. Active cigarette smoking or AT1R C variant significantly increase the risk for stroke in women with a high BMI compared with controls.
Nica, S., Nica, R.I., Toma, M., Cimponeriu, D., Cirstoiu, F.C., & Cimpoesu, D.C. (2025). The interactions between risk factors for ischemic stroke. Romanian Journal of Military Medicine, 124(1), 119-123.
Nica S, Nica RI, Toma M, Cimponeriu D, Cirstoiu FC, Cimpoesu DC. The interactions between risk factors for ischemic stroke. Rom J Mil Med. 2025;124(1):119-123.
Nica, S., Nica, R.I., Toma, M., Cimponeriu, D., Cirstoiu, F.C. & Cimpoesu, D.C. 2025, 'The interactions between risk factors for ischemic stroke', Romanian Journal of Military Medicine, vol. 124, no. 1, pp. 119-123.
