1 - Emergency University Hospital Bucharest
2 - Pathology Department, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest
Received: September 29, 2017
Accepted: November 14, 2017
Pathologists observed the presence of tumor infiltrating lymphocytes (TILs) in solid tumors many years before the research focus shifted from cancer cells to the tumoral microenvironment. In lung adenocarcinoma TILs vary in number, phenotype and distribution. Our study investigate the type and distribution of TILs regarding the stage of disease and histological subtype in 27 cases of lung adenocarcinoma. By immunohistochemistry we evaluated semi-quantitatively CD3, CD8 and cyclin D1. We have found that CD3+CD8- lymphocytes prevail at the invasive margin and in tumoral stroma. Cyclin D1 was diffusely positive in tumoral cells in all the five cases of lepidic type of lung adenocarcinoma. In other histological types cyclin D1 was focally positive, most at the margin of the tumor irrespective of the presence or absence of TILs.
Mihai, A., Simion, G., Florin, C., & Sajin, M. (2025). Study of the type and distribution of tumor infiltrating lymphocytes in 27 cases of lung adenocarcinoma. Romanian Journal of Military Medicine, 120(3), 24-28.
Mihai A, Simion G, Florin C, Sajin M. Study of the type and distribution of tumor infiltrating lymphocytes in 27 cases of lung adenocarcinoma. Rom J Mil Med. 2025;120(3):24-28.
Mihai, A., Simion, G., Florin, C. & Sajin, M. 2025, 'Study of the type and distribution of tumor infiltrating lymphocytes in 27 cases of lung adenocarcinoma', Romanian Journal of Military Medicine, vol. 120, no. 3, pp. 24-28.
