1 - Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; silvia.nica@umfcd.ro (SN); lucian.ciobica@umfcd.ro (MLC); matei- ioan.nica0720@stud.umfcd.ro (MIN)
2 - Molecular Biology Department, National Research and Development Institute for Food Bioresources – IBA Bucharest, Bucharest, Romania; robert.sionel@bioesurse.ro (RS)
3 - Faculty of Biology, University of Bucharest, Bucharest, Romania; maciuca.roxana-alexandra@s.bio.unibuc.ro (RM); danut.cimponeriu@bio.unibuc.ro (DC); iuliana-c@outlook.com (IC); irina.radu@bio.unibuc.ro (IR)
4 - Faculty of Medicine, Titu Maiorescu University, Bucharest, Romania; mihai.toma@prof.utm.ro (MT)
DOI: https://doi.org/10.55453/rjmm.2025.128.1.10
Received: 22 September 2024
Revised: 2 October 2024
Accepted: 15 November 2024
The digit ratio (2D:4D) has been associated with prenatal hormonal influences and various traits and pathologies. This article explores the relationship between 2D:4D and a series of common polymorphisms and Torque Teno Viruses. In this study, 120 healthy participants were included. The IGF2 Apa I, ACE I/D, INS -23 Hph I, VDR Fok I, VDR Apa I, VDR Taq I, AT1R A1166C polymorphism were genotyped by PCR-RFLP technique, and the IL-6 -174 G/C polymorphism by tetra-primer ARMS-PCR. The presence of TTV was identified by a hemi-nested PCR technique. Haplotype analyses were performed using the SHEsis software. The average 2D:4D values were similar for men and women. Overweight men presented higher 2D4D ratios than normal-weight women (p<0.05). Lower 2D:4D values were recorded in women with pregnancy loss or one child or none (p<0.001). Men with lower 2D4D ratios reported a higher number of children (p<0.001). The IGF2 GG and ACE DD were associated with a higher digit ratio in all subjects and in the women’s subset. A significant association was found in men between 2D:4D and the INS-23 Hph I – IGF2 Apa I T-G haplotype (p<0.01). The data obtained in this study indicate a sexual dimorphism for the digit ratio. The associations between 2D:4D and the genetic polymorphisms studied could be influenced by gender.
Nica, S; Sionel, R; M Cimponeriu, D; Ciobica, ML; Nica, MI; Chelu, I; Radu, I; Toma, M. Gender-Dependent Associations Between Digit Ratio and Genetic Polymorphisms, BMI, and Reproductive Factors. R. J. Mil. Med. 2025, 128(1): 78-86; https://doi.org/10.55453/rjmm.2025.128.1.10
ISSN: 1222-5126 (print), 2501-2312 (online)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Nica, S., Ciobica, M., Nica, M., Sionel, R., Cimponeriu, D., Măciucă, R., ... Toma, M. (2025). Gender-Dependent Associations Between Digit Ratio and Genetic Polymorphisms, BMI, and Reproductive Factors. Romanian Journal of Military Medicine, No.1 / 2025, Vol. CXXVIII, January. https://doi.org/https://doi.org/10.55453/rjmm.2025.128.1.10
Nica S, Ciobica M, Nica M, Sionel R, Cimponeriu D, Măciucă R, et al.. Gender-Dependent Associations Between Digit Ratio and Genetic Polymorphisms, BMI, and Reproductive Factors. Romanian Journal of Military Medicine No.1 / 2025, Vol. CXXVIII, January. 2025. DOI: https://doi.org/10.55453/rjmm.2025.128.1.10.
Nica, S. et al. 2025, 'Gender-Dependent Associations Between Digit Ratio and Genetic Polymorphisms, BMI, and Reproductive Factors', Romanian Journal of Military Medicine, No.1 / 2025, Vol. CXXVIII, January, DOI: https://doi.org/10.55453/rjmm.2025.128.1.10.
