1 - University of Medicine and Pharmacy „Carol Davila“, Bucharest, Romania
2 - Clinical Emergency Hospital of Bucharest, Bucharest, Romania
3 - Medical Center As-AIDE Sante, Bucharest, Romania
4 - Universitary Emergency Central Military Hospital, Academy of Romanian Scientists, Bucharest, Romania
5 - Department of Visceral Surgery, “Fundeni” Clinical Institute, Bucharest, Romania
6 - Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania
Received: March 25, 2020
Accepted: August 23, 2020
Fever of unknown origin (FUO) is a diagnosis that describes a prolonged febrile illness without an established cause, despite investigations. From the first definition of the medical condition (given by Petersdorf and Beeson in 1961) the diagnostic criteria have changed over time, intending to improve the management and outcome of these patients. The main causes of FUO fall into 4 categories: infectious, non-infectious (inflammatory), neoplastic and diverse causes. The etiology of FUO has changed over time, due to ever-changing disease patterns and the development of diagnostic techniques. A significant percentage of patients with FUO remain without an etiologic diagnosis, despite advanced diagnostic tests. Gathering potentially diagnostic clues through history, physical examination and nonspecific key paraclinical abnormalities is the basis for the diagnosis of FUO.
Gheorghe, G., Ceobanu, G., Gheorghe, F., Bratu, O.G., Bacalbasa, N., Bungau, S., & Diaconu, C.C. (2025). Fever of unknown origin. Romanian Journal of Military Medicine, 123(3), 213-218.
Gheorghe G, Ceobanu G, Gheorghe F, Bratu OG, Bacalbasa N, Bungau S, et al. Fever of unknown origin. Rom J Mil Med. 2025;123(3):213-218.
Gheorghe, G., Ceobanu, G., Gheorghe, F., Bratu, O.G., Bacalbasa, N., Bungau, S. & Diaconu, C.C. 2025, 'Fever of unknown origin', Romanian Journal of Military Medicine, vol. 123, no. 3, pp. 213-218.
