1 - “Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, Bucharest, 050474, Romania; iancuta@hotmail.com
2 - Department of Rheumatology, “Dr. I. Cantacuzino” Clinical Hospital, Ioan Movila Street, nr. 5-7, Bucharest, 020475, Romania
3 - Dermatology Department II, Colentina Clinical Hospital, Soseaua Stefan cel Mare 19-21, Bucharest, Romania; nedelcuirinel@yahoo.com
4 - Clinical Department, Faculty of Medicine and Pharmacy, ‘Dunarea de Jos’ University, 800008 Galati; stoleriugabriela@yahoo.com
5 - Department of Dermatology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi; debranisteanu@yahoo.com
6 - Department of Dermatology, Railway Clinical Hospital, 700506 Iasi, Romania
DOI: https://doi.org/10.55453/rjmm.2023.126.1.1
Received: October 12, 2022
Accepted: December 15, 2022
More than 75 years after its accidental discovery, methotrexate remains an important treatment option for many diseases. Whether it is various hematological and non-hematological neoplasms, rheumatological, dermatological, or other conditions, methotrexate remains in scope. For rheumatoid arthritis, current clinical guidelines (EULAR, ACR) recommend methotrexate as the first therapeutic option. This article aims to highlight important moments in the history of this remarkable drug, to review the literature on its mechanisms of action and the arguments for which after more than half a century, methotrexate remains the gold standard in the treatment of rheumatoid arthritis but also an important option for treatment of psoriasis vulgaris (PV) and psoriatic arthritis (PsA).
Ancuța, T.I., Nedelcu, I.A., Stoleriu, G., & Branisteanu, D.E. (2025). The amazing history of methotrexate – 75 years later from its discovery, still the “golden standard” therapy. Romanian Journal of Military Medicine, 126(1), 3-9. https://doi.org/10.55453/rjmm.2023.126.1.1
Ancuța TI, Nedelcu IA, Stoleriu G, Branisteanu DE. The Amazing History of Methotrexate – 75 Years Later from its Discovery, Still the “Golden Standard” Therapy. Rom J Mil Med. 2025;126(1):3-9. doi:10.55453/rjmm.2023.126.1.1.
Ancuța, T.I., Nedelcu, I.A., Stoleriu, G. & Branisteanu, D.E. 2025, 'The Amazing History of Methotrexate – 75 Years Later from its Discovery, Still the “Golden Standard” Therapy', Romanian Journal of Military Medicine, vol. 126, no. 1, pp. 3-9, doi:10.55453/rjmm.2023.126.1.1.
