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Cardiotoxicity of Chemotherapy in Lynch Syndrome – A Literature Review

Bogdan V. Vîlceleanu1, Oana C. Voinea1, 2, 3, Cosmin Buzila4, Diana M. Ciobanu1, Liviu Stan4, Silviu I. Dumitrescu1, 5

1 - Department of Cardiology, Carol Davila Emergency Military Hospital, Bucharest, Romania

2 - Department of Pathology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

3 - National Military Research Institute “Cantacuzino”, Bucharest, Romania

4 - Department of Cardiovascular Surgery, Carol Davila Emergency Military Hospital, Bucharest, Romania

5 - Faculty of Medicine, Titu Maiorescu University, Bucharest, Romania

Correspondence: Bogdan-Viorel Vîlceleanu, bogdan.vilceleanu@gmail.com

DOI: https://doi.org/10.55453/rjmm.2023.126.5.1

Received: August 16, 2023

Accepted: October 1, 2023

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Abstract:

Chemotherapy is an important treatment in oncological disease, with a vast number of side effects. The cardiotoxicity of several chemotherapeutic agents and appropriate risk stratification and patient follow-up must be ensured by a multidisciplinary team which must include an oncologist and a cardiologist. Lynch syndrome is associated with younger-onset malignant tumors of various localizations, requiring aggressive chemotherapy. FOLFOX chemotherapy which is frequently used in Lynch syndrome-associated colorectal cancer has several cardiotoxic effects with mechanisms ranging from increased reactive oxidative species to Krebs cycle blockade or coronary vasospasm. These complex effects on the cardiovascular system have varied clinical effects, such as heart failure, arrhythmias, or acute ischemic events.

Keywords:
bradycardia, cardio-oncology, cardiotoxicity, chemotherapy, colon cancer, FOLFOX, heart failure, Lynch syndrome

Cardiotoxicity of Chemotherapy in Lynch Syndrome – A Literature Review

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APA Style

Vîlceleanu, B.V., Voinea, O.C., Buzila, C., Ciobanu, D.M., Stan, L., & Dumitrescu, S.I. (2025). Cardiotoxicity of chemotherapy in lynch syndrome – a literature review. Romanian Journal of Military Medicine, 126, 3-11. https://doi.org/10.55453/rjmm.2023.126.5.1

Vancouver Style

Vîlceleanu BV, Voinea OC, Buzila C, Ciobanu DM, Stan L, Dumitrescu SI. Cardiotoxicity of Chemotherapy in Lynch Syndrome – A Literature Review. Rom J Mil Med. 2025;126:3-11. doi:10.55453/rjmm.2023.126.5.1.

Harvard Style

Vîlceleanu, B.V., Voinea, O.C., Buzila, C., Ciobanu, D.M., Stan, L. & Dumitrescu, S.I. 2025, 'Cardiotoxicity of Chemotherapy in Lynch Syndrome – A Literature Review', Romanian Journal of Military Medicine, vol. 126, pp. 3-11, doi:10.55453/rjmm.2023.126.5.1.