1 - Carol Davila University Central Emergency Military Hospital, Bucharest, Romania
2 - Titu Maiorescu University, Faculty of Medicine, Bucharest, Romania
3 - Saint John Emergency Clinical Hospital, Bucharest
Received: August 12, 2017
Accepted: September 10, 2017
Yolk sac tumor or endodermal sinus tumor is a rare malignant ovarian germ cell tumor (is a borderline tumor) diagnosed in young females up to 25 years old. Histopathological it resembles the mesenchyme of the primitive yolk sac. Microscopically it presents the following triad: Schiller-Duval bodies, reticular aspect and PAS+ hyaline droplets (α-fetoprotein). The diagnosis of Yolk sac tumor is made by dosing serum α-fetoprotein, ultrasound and MRI – DWI imaging. It requires surgical treatment, followed by chemotherapy (new therapies – platin or carboplatin, etoposide, bleomycin) [1]. Survival prognosis at 5 years is of 80% for stage I. Differential diagnosis is with Brenner tumor, ovarian clear cell carcinoma, dysgerminoma, malignant teratomas, androblastoma, dermoid cyst.
Negoiță, I.A., Panaite, B., Nicodin, O.V., & Nanu, D. (2025). Yolk sac tumor in a 20 years old patient. Romanian Journal of Military Medicine, 120(3), 56-59.
Negoiță IA, Panaite B, Nicodin OV, Nanu D. Yolk sac tumor in a 20 years old patient. Rom J Mil Med. 2025;120(3):56-59.
Negoiță, I.A., Panaite, B., Nicodin, O.V. & Nanu, D. 2025, 'Yolk sac tumor in a 20 years old patient', Romanian Journal of Military Medicine, vol. 120, no. 3, pp. 56-59.
