Purpose – Combined airway burns with cutaneous burns is a further negative prognostic factor in burn patients. In this study we tried to identify the most relevant negative prognostic factors at admission in a relatively homogeneous population. Methods – In this study, ten young patients who suffered from skin and airway burns following a fire in a club, admitted to our ICU department, were included. At the intake, ABSI and APACHE II scores were calculated, and a series of biomarkers were also collected. The correlation and associations between gravity scores and biomarkers was then calculated using the Spearman correlation and Chi square tests. Results – Based on data analysis, we found very high values of ABSI 8.9 ± 1.4 and APACHE II 25.4 ± 2.79 scores, procalcitonin (46.16 ± 68.18 ng/ml), white blood cells (41.26 ± 15.66 × 103/mm3), hematocrit (51.6 ± 7.31 %), and low corrected albumin values (22.08 ± 4.66 g/l). The statistical analysis revealed a good correlation between gravity scores and values of PCT and low albumin levels (p< 0.05). The mortality was also associated with the need for vasopressor support from the beginning (p < 0.05). Conclusions – Adverse prognostic factors that we have identified in this group of young patients with skin burns and airway include: increased values of the severity scores and PCT, low values of corrected albumin and vasopressor support necessary at admission. INTRODUCTION Burns represent one of the most aggressive injuries of the human body known for high mortality, thus raising major length of public health hospitalization and recuperation, along with psychological and physiological traumas, all these leading to increased costs [1-4]. issues such as increased Burns-induced mortality rate is globally increased, and 1 Clinical Emergency Hospital of Plastic Reconstructive Surgery and Burns, Bucharest, Romania 2 Carol Davila University of Medicine and Pharmacy, Division of Physiology and Neurosciences, Bucharest, Romania 3 The Bucharest University of Economic Studies, Department of Statistics and Econometrics, Bucharest, Romania 22 including surprisingly high in the developing countries, including Europe’s burn centers, where it ranges between 1.4% and 18% [5]. The high mortality is associated with a number of factors, long-term severity of burn driven inflammatory response of the host, secondary human body frailty and abnormal response to further injuries like sepsis [6, 7]. The association of airways’ and cutaneous burns induces a supplemental inflammatory response, difficult to quantify because of the inaccurate evaluation of the burns from the surface of the lungs and burn degree same time [8]. Consequently, in the case of mixed cutaneous-and-airway burns the mortality increases, increase of the Corresponding author: Bogdan I. Pavel, MD, PhD bogdan.pavel@umfcd.ro
